This project, entitled “Mitigating zoonotic disease emergence risk in wildlife trade in Southeast Asia”, integrates three key components – scientific method and evidence, human behavior change, and policy – into pilot studies to form One Health-based risk-mitigation strategy targeting zoonotic spillover risk in the wildlife trade, aiming to establish an interdisciplinary and cross-sectoral network to facilitate communication and foster collaborations among scientists, policymakers, and communities to promote One Health collaborations in preventing zoonotic disease emergence in the wildlife trade. The project will showcase One Health approaches to address the challenges at the interconnections of conservation and public health, facilitate dialogue among stakeholders to support evidence-based policymaking, and translate policy into local-context practices.